T-cell vaccination: from basics to the clinic.

References 1 Pap, T. et al. (2000) Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis. Arthritis Res. 2, 361–367 2 van der Laan, W.H. et al. (2000) Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of a cellsurface-targeted plasmin inhibitor. Arthritis Rheum. 43, 1710–1718 3 Mountz, J.D. et al. (2001) Apoptosis and rheumatoid arthritis: past, present and future directions. Curr. Rheumatol. Rep. 3, 70–78 4 Lubberts, E. et al. (2001) IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis. J. Immunol. 167, 1004–1013 5 Watanabe, S. et al. (2000) Adeno-associated virus mediates long-term gene transfer and delivery of chondroprotective IL-4 to murine synovium. Mol. Ther. 2, 147–152 6 Douar, A.M. et al. (2001) Intracellular trafficking of adeno-associated virus vectors: routing to the late endosomal compartment and proteasome degradation. J. Virol. 75, 1824–1833 7 Ghivizzani, S.C. et al. (2001) Direct gene delivery strategies for the treatment of rheumatoid arthritis. Drug Discov. Today 6, 259–267 8 Peterson, L. et al. (2000) Twoto 9-year outcome after autologous chondrocyte transplantation of the knee. Clin. Orthop. 374, 212–234 9 Lisignoli, G. et al. (2001) Basic fibroblast growth factor enhances in vitro mineralization of rat bone marrow stromal cells grown on nonwoven hyaluronic-acid-based polymer scaffold. Biomaterials 22, 2095–2105 10 Turgeman, G. et al. (2001) Engineered human mesenchymal stem cells: a novel platform for skeletal-cell-mediated gene therapy. J. Gene Med. 3, 240–251 11 Moutsatsos, I.K. et al. (2001) Exogenously regulated stem-cell-mediated gene therapy for bone regeneration. Mol. Ther. 3, 449–461